The future of medicine
Development of design & fabrication technologies that enable the local control of (bio) material composition and structure across multiple length scales is fundamental to understand complex regenerative processes in the human body; as well as to develop approaches for functional restoration of damaged&diseased tissues and organs. To address this challenge, Castilho team uses a material-by-design approach, combining advanced 3D printing technologies and computational design, to develop instructive materials for regenerative medicine, particularly of musculoskeletal tissues, like bone.
Eindhoven University of Technology (TU/e)
Advanced Therapy Medicinal Products are a class of advanced medicines based on the use of living cells. These living drugs are based on (stem) cells or tissues often cultured or enhanced with therapeutic genes in the laboratory before administration to the patient. These living drugs are promising durable treatment options for chronic and life-threatening diseases such as cancer. An example is so called CAR T cell therapy approved and used for the treatment of leukemia.
Trudy Straetemans will discuss another approach named TEG therapy and the promises and challenges of these living drugs.
Special delivery: a message from your cells
Our bodies consist of trillions of cells which maintain a stable environment within our body, called homeostasis, which is optimal for our functioning and survival. An important process in maintaining this stable environment, is communication between cells. This can happen through direct contact or by releasing substances to communicate larger distances. Recently a new process in cell-to-cell communication has entered the spotlights: extracellular vesicles. These are small particles that play a role in communication by transferring proteins and RNA molecules. What is their function? And can we use them as a new tool for delivery of biotherapeutics?
Olivier de Jong
Assistant Professor at the Department of Pharmaceutics